It happened in Ogontz section, on the 5900 block of North 21st Street, just before 6 p.m., the department said.
A 17-year-old boy was shot in the face and driven to Albert Einstein Medical Center where he was pronounced dead, police said.
The 7-year-old victim was shot once in the upper thigh and is in stable condition, they continued. A 15-year-old boy who was shot twice in the back and twice in the head is also in stable condition, as is a 16-year-old boy who was hit once in the shoulder, police added.
No arrest has been made, and no weapons were recovered from the scene as of Thursday evening.
Click here to follow Daily Voice Bethlehem and receive free news updates.